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assessment of hematologic, hepatic, renal, and pulmonary function should be made by history, physical examination, and laboratory tests before beginning, periodically during, and before reinstituting methotrexate therapy.

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methotrexate can cause damage to your liver, especially if it is used over a long period of time.

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while methotrexate usually begins to show effects after a few weeks, it could be six to 12 weeks before you notice any significant benefit, says thomas j.

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